An investigation of the impact of body condition score on the grade of intervertebral disc disease and recovery time

Background: Risk factors for Hansen type I intervertebral disc disease (IVDD) have been widely investigated, but studies looking at the impact of body condition score (BCS) on recovery times have had many limitations. Aims: To investigate whether BCS is associated with IVDD grade; and whether BCS affects recovery time following thoracolumbar hemilaminectomy in Dachshunds. Methods: An owner questionnaire was shared through social media between 11 November 2021 and 11 January 2022. 294 responses were received from owners of Dachshunds that had had thoracolumbar hemilaminectomies. Data on Dachshund variety, age, gender and neuter status were collected as well as information about the time of developing IVDD including age, weight and BCS using a Dachshund specific scale. Postoperative data included days spent in hospital and times to consciously urinate and to walk without assistance. BCS was then compared with IVDD grade, recovery time (days in hospital, days to urinate, days to walk unaided) to look for any significant differences. Results: BCS was not associated with grade of IVDD (p=0.566). There was no significant association between body condition and days to walk unaided or days in hospital. However, there was an association between body condition and number of days to consciously urinate (p=0.016). Conclusion: Dachshunds that are overweight (BCS ≥ 6) took longer to consciously urinate following IVDD surgery than those of ideal weight. This is new evidence that being overweight can delay time to consciously urinate, highlighting the importance of maintaining ideal BCS in this breed, which commonly suffers with IVDD. No conclusion could be drawn about underweight Dachshunds from this study and so further research about underweight dogs is required

Public rules about using and owning real estate in Cuba

The discussion on urban land continues to be absent in most of the specialized Cuban literature about planning and economic policies, despite its relevance. In very thorough essays about the present challenges and future development of the Cuban economy, nothing is said about the need for adequate public land policies and the implementation of public value capture mechanisms as part of the economic development of the country. The issue is complex, there is a void of almost half a century of not dealing with land value, but these reasons are not sufficient to justify the continued lack of vision in this direction, all the more when the Cuban cities are in desperate need to reverse the deterioration and stagnation that affects them. The Cuban state determines the general rules under which citizens and organisations may own and use real estate. These are rules about property rights and about the limitations - in compliance with aspects such as state security, environmental and heritage protection, economic development, social equity and human and civil rights – on exercising those rights. In doing this, the Cuban state is no different from other states: most states make such rules and enforce them when necessary. What is particular to Cuba is the content of those rules. In particular, the Cuban state has the monopoly to perform land development and management. There are public institutions to plan and deal with all of these aspects, and there are no recognised real estate markets in the country. Another important aspect is the utmost importance given to planning. But in spite of this, Cuban urban planners have rarely been certain of what will be built and where. The main reason for this may be that, despite the numerous master plans to study and anticipate development trends, most of the decisions ultimately involve top officials who envision the projects and establish the investment priorities according to the public interests or needs and the historical moment, irrespective of the plans. This article intends to give a clear picture of how things are done in the public sector, how the administration works, and under which legal framework. I will look at the physical planning system and its importance in the location and implementation of land use, investment projects and housing programs, and at the legal procedures that include licenses for construction, demolition, habitat and other licenses for heritage conservation and redevelopment. I will analyze the difficulties faced by the Cuban planning and legal system with respect to land and urban development, in the attempt to understand the limits imposed by the government on land and urban development, and I will explore to what extent those limits are to blame for the increasing irregularities and violations at all levels of the formal procedures for land and property. I will also introduce the public and personal rights concerning housing, buying and selling, permutes, donations and other tenure alternatives; and clarify the civil responsibilities, namely types of ownership, properties, property registers and so forth in order to expose the opportunities and accessibility of the system but also its limitations

Lattice Study of the Decay B^0-bar -> rho^+ l^- nu_l-bar: Model-Independent Determination of |V_{ub}|

We present results of a lattice computation of the vector and axial-vector current matrix elements relevant for the semileptonic decay B^0-bar -> rho^+ l^- nu_l-bar. The computations are performed in the quenched approximation of lattice QCD on a 24^3 x 48 lattice at beta = 6.2, using an O(a) improved fermionic action. Our principal result is for the differential decay rate, dGamma/dq^2, for the decay B^0-bar -> rho^+ l^- nu_l-bar in a region beyond the charm threshold, allowing a model-independent extraction of |V_{ub}| from experimental measurements. Heavy quark symmetry relations between radiative and semileptonic decays of B-bar mesons into light vector mesons are also discussed.Comment: 22 pages LaTeX-209 (dependent on settings in a4.sty), 23 PostScript figures included with epsf.sty. Complete PostScript file including figures available at http://wwwhep.phys.soton.ac.uk/hepwww/papers/shep9518

Study of the radiative decay ϕ→ηγ\phi \to \eta \gamma with CMD-2 detector

Using the $1.9 pb^{-1}$ of data collected with the CMD-2 detector at VEPP-2M the decay mode $\phi \to \eta \gamma$, $\eta \to \pi^+\pi^-\pi^0$ has been studied. The obtained branching ratio is B($\phi \to \eta \gamma) = (1.18 \pm 0.03 \pm 0.06)$.Comment: 13 pages, 5 figures, LaTex2e, to be published in Phys. Lett.

Automated Classification of Sloan Digital Sky Survey (SDSS) Stellar Spectra using Artificial Neural Networks

Automated techniques have been developed to automate the process of classification of objects or their analysis. The large datasets provided by upcoming spectroscopic surveys with dedicated telescopes urges scientists to use these automated techniques for analysis of such large datasets which are now available to the community. Sloan Digital Sky Survey (SDSS) is one of such surveys releasing massive datasets. We use Probabilistic Neural Network (PNN) for automatic classification of about 5000 SDSS spectra into 158 spectral type of a reference library ranging from O type to M type stars.Comment: 27 pages, 11 figures To appear in Astrophys. Space Sci., 200

Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays

Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should adequately reflect the burden of somatic mutations in the tumor being sequenced. Here, we sought to determine the prevalence of clonal hematopoiesis leading to possible misattribution of tumor mutation calls on unpaired Foundation Medicine NGS assays. Experimental Design: This was a retrospective cohort study of individuals undergoing NGS of solid tumors from two large cancer centers. We identified and quantified mutations in genes known to be frequently altered in clonal hematopoiesis (DNMT3A, TET2, ASXL1, TP53, ATM, CHEK2, SF3B1, CBL, JAK2) that were returned to physicians on clinical Foundation Medicine reports. For a subset of patients, we explored the frequency of true clonal hematopoiesis by comparing mutations on Foundation Medicine reports with matched blood sequencing. Results: Mutations in genes that are frequently altered in clonal hematopoiesis were identified in 65% (1,139/1,757) of patients undergoing NGS. When excluding TP53, which is often mutated in solid tumors, these events were still seen in 35% (619/1,757) of patients. Utilizing paired blood specimens, we were able to confirm that 8% (18/226) of mutations reported in these genes were true clonal hematopoiesis events. The majority of DNMT3A mutations (64%, 7/11) and minority of TP53 mutations (4%, 2/50) were clonal hematopoiesis. Conclusions: Clonal hematopoiesis mutations are commonly reported on unpaired NGS testing. It is important to recognize clonal hematopoiesis as a possible cause of misattribution of mutation origin when applying NGS findings to a patient's care

Fitting the integrated Spectral Energy Distributions of Galaxies

Fitting the spectral energy distributions (SEDs) of galaxies is an almost universally used technique that has matured significantly in the last decade. Model predictions and fitting procedures have improved significantly over this time, attempting to keep up with the vastly increased volume and quality of available data. We review here the field of SED fitting, describing the modelling of ultraviolet to infrared galaxy SEDs, the creation of multiwavelength data sets, and the methods used to fit model SEDs to observed galaxy data sets. We touch upon the achievements and challenges in the major ingredients of SED fitting, with a special emphasis on describing the interplay between the quality of the available data, the quality of the available models, and the best fitting technique to use in order to obtain a realistic measurement as well as realistic uncertainties. We conclude that SED fitting can be used effectively to derive a range of physical properties of galaxies, such as redshift, stellar masses, star formation rates, dust masses, and metallicities, with care taken not to over-interpret the available data. Yet there still exist many issues such as estimating the age of the oldest stars in a galaxy, finer details ofdust properties and dust-star geometry, and the influences of poorly understood, luminous stellar types and phases. The challenge for the coming years will be to improve both the models and the observational data sets to resolve these uncertainties. The present review will be made available on an interactive, moderated web page (sedfitting.org), where the community can access and change the text. The intention is to expand the text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics & Space Scienc

New measurement of the rare decay ϕ→η′γ\phi \to \eta' \gamma with CMD-2

A new measurement of the rare decay \phi \to \eta' \gamma performed with the CMD-2 detector at Novosibirsk is described. Of the data sample corresponding to the integrated luminosity of 14.5 pb^{-1}, twenty one events have been selected in the mode \eta'\to\pi^+\pi^-\eta, \eta\to\gamma\gamma. The following branching ratio was obtained: B(\phi \to \eta' \gamma) = (8.2^{+2.1}_{-1.9} \pm 1.1) 10^{-5}.Comment: 12 pages, 4 figures, LaTe